Viagra (Sildenafil Citrate) 100 mg 20 tabs Teragon Labs

Information about the drug

Viagra (the active ingredient is sildenafil) is a popular tool for improving erectile function in men, however, recently this drug has found wider application both in medicine and in bodybuilding.

Many believe that Viagra is another nitrogen donor, but this is not so. It does not affect the level of NO, but the vessels in the muscles do expand. If true nitric oxide donors increase the level of NO, which increases the concentration of cellular cGMP, which triggers a cascade of reactions, which ultimately leads to relaxation of the vascular wall, Viagra blocks the enzyme phosphodiesterase-5, which destroys cGMP, so its concentration also begins to increase, and the same end result is obtained.

There are a number of advantages that make the use of Viagra in bodybuilding the most promising. The drug slightly reduces blood pressure, has a positive effect on the heart, effectively improves blood flow in the muscles and causes a minimum of side effects. At the same time, it is repelled by a very high cost, but there are cheaper generics (dynamically).

Some mistakenly believe that taking Viagra causes a permanent erection, but this is not so. In the absence of sexual arousal (stimulation), an erection as a rule never occurs.

Properties of the Sildenafil are used not only for increasing potency, but in sports also. Viagra is a type of doping that can increase athlete’s productivity for some time. Thanks to better blood access to the body’s tissues appears burst of energy and endurance increases. It is because of high oxygen content.

Viagra is very popular in bodybuilding – medicine leads to the better rush of blood to the trained muscle, athlete feels light pumping. Matched with anabolic steroids the effect redoubles, as blood permeate fat deposits better, hormones that start lipolysis too. So, there are several useful processes for bodybuilders.

Pharmacological properties

Pharmacodynamics

The physiological mechanism involves the release of nitric oxide (NO). The released nitric oxide activates the guanylate cyclase enzyme, which stimulates the increase of cyclic guanosine monophosphate (cGMP).

Effect on pharmacodynamics:

In vitro studies have demonstrated that sildenafil is selective for PDE5. The effect of sildenafil on PDE5 is more potent than on other known phosphodiesterases. This effect is 10 times more powerful than the effect on PDE6 involved in retinal photoreformation. In particular, the selectivity of sildenafil for PDE5 is 4,000 times greater than its selectivity for PDEZ, a cAMP-specific phosphodiesterase isoform involved in the regulation of cardiac contractility.

Pharmacokinetics

Absorption: Sildenafil is rapidly absorbed. The maximum plasma concentration of the drug is reached within 30-120 minutes after its oral fasting. The average absolute bioavailability after oral administration is 41%. In the recommended dose range (25 to 100 mg), the sildenafil AUC and Cmax after oral administration increase in proportion to the dose.

When using sildenafil while eating, the degree of absorption decreases with an average Tmax elongation of up to 60 minutes and an average Cmax decrease of 29%.

Distribution: The average equilibrium volume of distribution is 105 liters, which indicates the distribution of the drug in the tissues of the body. After single oral administration of 100 mg sildenafil, the mean maximum total plasma concentration of sildenafil is approximately 440 ng / ml. Because the binding of sildenafil and its major N-desmethyl metabolite to plasma proteins is 96%, the mean maximum plasma concentration of free sildenafil is 18 ng / ml (38 nmol). The degree of plasma protein binding is independent of total sildenafil concentrations.

Biotransformation: Sildenafil metabolism is mainly by the involvement of the microsomal isoenzymes of the liver CYP3A4 (major pathway) and CYP2C9 (minor pathway). The major circulating metabolite is formed by N-demethylation of sildenafil. The metabolite selectivity for PDE5 is comparable to that of sildenafil, and the metabolite activity for PDE5 is approximately 50% of the activity of the starting material. The plasma concentration of this metabolite is approximately 40% of the concentration of sildenafil in blood plasma. The N-demethylated metabolite undergoes further metabolism, and its half-life is approximately 4 hours.

Elimination: Sildenafil's total clearance is 41 l / h, resulting in a half-life of 3–5 hours.

Applying

To use Viagra in therapeutic ways, usually applies 50mg (a half of the tablet) in 40-45 minutes before the act.

In bodybuilding the drug is usually used by professionals, their dose is 100mg a day in 30-60 minutes before the training, considering the warm-up – the medicine will act completely before doing main exercises.

The action of Viagra continues for 6 hours as usual, cells’ susceptibility to the anabolic steroids increases, so athlete can make the endurance better and trains longer, that helps to gain nice result.

Contraindications:

• Hypersensitivity to the active substance or any of the excipients of the drug.
• The simultaneous use with nitric oxide donors (such as amyl nitrite) or nitrates in any form is contraindicated, since it is known that sildenafil affects the metabolism of nitric oxide / cyclic guanosine monophosphate (cGMP) and potentiates the hypotensive effect of nitrates.

 Side effects

The product has not strict contraindications, but if you use any drug for heart treatment learn about its joint application.

This drug mustn’t be matched with alcohol – it can be the reason of some side effects. Applying big doses can cause such symptoms:

• Extremities swelling;
• Headache;
• Pain in the chest;
• Diarrhea;
• Nose bleeding.

Warning!

This drug is medical product and requires following recommendations of using and storing. It should be stored in the cool dark place, avoiding direct sunlight. It’s also necessary to prevent applying this drug by children.

You MUST consult with your attending physician before you start using this drug. We also ask you to take into account that this drug may cause some side effects, some of them can be life-threatening. If you notice any disturbing symptoms you should to contact with your physician. In some cases, it is necessary to stop taking the drug for a while. Also you must inform your doctor if you taking this drugs with other medicines. So physician can prescribe proper treatment and help to avoid any unpleasant adverse effects.